Molecular Advances in Aging and Neurodegenerative diseases by emerging Mechanism, Biomarker and Therapeutic purpose: A Review

Abstract

Aging is a major hazard for many neurodegenerative diseases that decline our body movements, and it is included with Alzheimer’s disease, Parkinson’s disease all these were affected in human health. In aging due to the global population increases rapidly in number of individuals. It is a major complex risk factor and biological process for diseases. In humans Alzheimer’s disease causes dementia in adults. All these diseases are caused by genetic mutation from the production of abnormal proteins which deposit in our brain cell that leads to memory loss and cognitive decline. The blood brain barrier is a semi permeable membrane which is obtained from sensitive monitoring diseases which are efficient in drug delivery. In India over 138 million in individuals aged 60 or above constitute from the disorders about 10% of population are expected that in future it rises 20%. It produces a disease in the brain cells by oxidative stress due to cytotoxic consequences and produces the changes in phosphodiesterase-fatty acid. A biomarker like homocysteine and apolipoprotein (ApoE4) in treatment of vascular risk factors in disease development, and synaptic marker measure the blood or brain tissue to assess the synaptic damage. The benefit is that it leads to a better understanding and treatment of the (CNS) and develops a remarkable adaptability. The aim is to study the area of improving the public health issues from the increasing aging population by identifying the degeneration in advancing field as the biomarkers emerges for better clinical research and examining the therapeutic strategies for the prevention of the diseases.