Synthesis and Microbial Activities of 2, 5, 6-Substituted Benzimidazole Derivatives

Abstract

Benzimidazole derivatives are the analogues of purine nucleosides which are found in human body. These are an important heterocyclic organic compounds containing phenyl ring (six membered ring) fused with imidazole (five membered ring) which possesses wide range of starting material for various compounds and exhibit clinical applications such as anti-inflammatory, antibacterial, antifungal, antiviral, analgesic, proton pump inhibitors, antihistamines, anticancer, etc. The presence of electron-donating groups (OH, -CH3, -OCH3) causes significant increase in the biological activity, while the electron-withdrawing groups (-Cl, -Br,–NO2) decreases the biological activity of synthesized of benzimidazole derivatives.