BUTTERING CANCER: A Novel Phytonutraceutical in Cancer Prevention and Treatment from Bunchosia Glandulifera (Peanut Butter Tree)

Abstract

Cancer is a disease characterized by an abnormal growth of cells that can start in any organs affecting tens of millions of people every year. Conventional therapy of disease offers a success but remained as a challenge due to its negative adverse effects. This study aims to determine the phytonutraceutical, anti-angiogenic, and antioxidant properties of Bunchosia glandulifera (Peanut Butter Tree). Ethanolic leaf extract of B. glandulifera was subjected to phytochemical screening and tested for anti-angiogenic, cytotoxic, and antioxidant activity. Secondary metabolites screening indicates the presence of alkaloids, flavonoids, saponin, and phenols. Test for angiosupressive activity revealed a positive anti-angiogenic property at 25%, 50%, and 75% concentration. The probit analysis of the leaf extract was found to be 309.7µg/ml. LC50 of the extract was higher than 100 microgram which indicates that the extract has low toxicity towards human cells. Evaluation for antioxidant property of the leaf extract exhibits an IC50 value of 35.39 µg/ml. The results revealed that B. glandulifera exhibit a promising source of phytonutraceutical, anti-angiogenic, as well as antioxidant property which can be a novel cancer prevention and treatment. Isolation of potent bioactive compounds and in vivo testing of B. glandulifera must be done to further validate the claim of the study.